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Zolazepam is a benzodiazepine agonist, enhances the effect of tiletamine on the central nervous system and decreases skeletal muscle hyperactivity. In high doses, TZ depresses the respiratory system and recovery may be complicated; therefore, proper attention to anaesthesia is required in dogs with respiratory and neurological disease. Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine.

What is Zolazepam Hydrchloride?

Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water soluble and un-ionized at physiological pH meaning that its onset is very fast. A pyrazolodiazepinone with pharmacological actions similar to ANTI-ANXIETY AGENTS. It is commonly used in combination with TILETAMINE to obtain immobilization and anesthesia in animals.

How to use Benzodiazepine Agonist?

Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be superior to ketamine because of reduced side-effects. A 1:1 mixture of zolazepam and tiletamine is sold under the names Telazol and Zoletil. It is around four times the potency of diazepam (0.32 mg/kg versus 1.2 mg/kg in animal models) but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.

Effect of Pyrazolodiazepinone Derivative

Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke-Davis and was the result of a very detailed analysis of the benzodiazepine structure

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