Xylazine Hydrochloride – Xylazine Hcl Powder – CAS 7361-61-7


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Xylazine Hydrochloride is a thiazine derivative used in veterinary medicine as the hydrochloride for sedation, analgesia, muscle relaxation and for anaesthetic premedication. It is available as 2% injectable solution and as a dry substance with solvent for intravenous or intramuscular injection.


Xylazine Hydrochloride is a potent alpha-2 adrenergic agonist and is structurally related to clonidine, an antihypertensive agent recommended for human therapy. Its spectrum of effects is therefore, similar to that of clonidine. The primary pharmacodynamic effects of Xylazine Hydrochloride following intravenous or intramuscular administration in mice, rats, rabbits, dogs and cats as well as in cattle, horses, sheep, goats and pigs were sedation, analgesia and muscle relaxation. There were marked species differences with cattle being the most sensitive species requiring approximately 1/10 of the dose used to induce an equivalent sedative state in horses, dogs and cats.

What is Xylazine Hydrochloride?

Xylazine Hydrochloride is not authorised for use in human medicine. In some earlier experiments however, it was demonstrated to be effective in lowering  blood pressure and heart rate in 6 patients with essential hypertonia after single oral doses of 10 to 20 mg/person, equivalent to 0.17 to 0.3 mg/kg bw. In healthy volunteers, xylazine induced  sedationanesthesiamuscle relaxation after single intravenous doses of 0.27 or 0.68 mg/kg bw or a single oral dose of 0.54 mg/kg bw. At all dose levels xylazine produced a significant depression in blood pressure and heart rate for several hours.

Effects of Xylazine Hydrochloride?

Xylazine was transformed into a number of polar and non-polar products. The metabolic pathway was qualitatively similar to that observed in rats, namely hydroxylation of the phenyl ring, conjugation with glucuronic acid, oxidation/opening of the thiazine ring.: The major metabolites were present as glucuronide conjugates in extracted urine.

When to use Xylazine Hcl?

xylazine is used in a small number of individual animals for non regular treatments, the treated animals are unlikely to be sent for slaughter during or immediately after treatment, xylazine is very rapidly and extensively metabolized in cattle tissues and is very rapidly
excreted, depletion of total xylazine residue in cattle tissues was very rapid with total residues and parent xylazine hydrochloride residues in the standard edible tissues portion after 24 hours post dose being as low as 14 µg and 0.6 µg, respectively. 2,6-xylidine is not found in cattle urine and tissues and no metabolites derived from cleavage of the thiazine and the phenyl ring or decomposition of the thiazine ring are present in cattle tissues, inadequate data on residue depletion in milk were available and in particular that the composition of residues in milk is unknown

Where to get pure Xylazin hydrochloride online?

Additional information

10g, 50g, 200g, 500g

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