JWH-018 has been identified in herbal incense mixtures, with names including “Spice”, “K2”, and others, sold via the Internet, gas stations, convenience stores, tobacco shops and head shops. It is a synthetic cannabinoids agonist without the classical cannabinoid chemical structure. JWH-018 was used in scientific research as a tool to study the cannabinoid system.
What is JWH-018?
The primary abusers are youth purchasing these substances from Internet websites, gas stations, convenience stores, tobacco shops and head shops. JWH-018 substance has no known legitimate use outside of research and is purposely spiked on plant material. It has been identified in numerous herbal incense products including “Spice”, “K2”, and other similar products which are smoked for their psychoactive effects.
How to use AM-678 Solution?
In vitro studies show that JWH-018 binds to the brain cannabinoid receptor CB1 with increased affinity relative to Δ9-THC and displays agonist properties in functional assays, suggesting that it would have the same effects as Δ9-THC in vivo. In drug discrimination studies in rats, JWH 018 generalized to Δ9-THC, i.e. produced subjective effects
similar to those of Δ9-THC
What are the effects of Synthetic Cannabinoids?
Behavioral pharmacology studies show that JWH-018 has Δ9-THC-like activity in animals. In mice, it decreases overall activity, produces analgesia, decreases body temperature and produces catalepsy. Together, these four effects are used by scientists to predict Δ9-THC-like psychoactivity in humans. AM-678 activity in all four tests
suggests that it is likely to have THC-like psychoactive effects in humans.
When to take Cannabis Powder?
JWH-018 (1-pentyl-3-(1-naphthoyl)indole or naphthalen-1-yl-(1-pentyl-1H-indol-3-yl)methanone) [Chemical Abstract Service (CAS) Registry Number 209414-07-3] has been identified as a substance that has some pharmacological similarities to the primary psychoactive constituent in marijuana (Cannabis sativa L.),Δ9-THC. JWH-018 was developed and evaluated in basic scientific research to study structure activity relationships related to the cannabinoid receptors.
Other names: Spice, K2, Synthetic Cannabinoids
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