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Etizolam Powder is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, amnesic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983 in Japan as treatment for neurological conditions such as anxiety and sleep disorders.

What is Etizolam Powder?

Etizolam Hcl online is marketed in Japan, Italy and India. It is not approved for use by FDA in the US; however it remains unscheduled in several states and is legal for research purposes. Indicated for the treatment of generalized anxiety disorder with depression, panic disorder and insomnia.

How to Use Etizest Powder?

Etizolam Powder online is a CNS depressant with anxiolytic, anticonvulsant, sedative-hypnotic and muscle relaxant effects. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABA ergic transmission throughout the central nervous system.

How does Etilaam Powder reacts in the body?

Studies indicate that Etizolam Powder online mediates its pharmacological actions with 6 to 10 times more potency than that of diazepam. Clinical human studies performed in Italy showed clinical effectiveness of Etizolam Hcl online in relieving symptoms in patients with generalized anxiety disorders with depressive symptoms.

How long should i take Etilaam Powder?

Etizolam Powder also mediates imipramine-like neuropharmacological and behavioral effects, as well as minor effects on cognitive functioning. It is shown to substitute the actions of a short-acting barbiturate, pentobarbitol, in a drug discrimination study.

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Etizolam Powder is an antagonist at platelet-activating-factor (PAF) receptor and attenuates the recurrence of chronic subdural hematoma after neurosurgery in clinical studies. It is shown to inhibit PAF-induced bronchoconstriction and hypotension ⁵.

How to take Etizolam Powder with other drugs:

Etizolam is selectively a full agonist at GABA-A receptors to increase GABA ergic transmission and enhance GABA-induced Cl- currents ¹. It is reported to bind to the benzodiazepine binding site which is located across the interface between the alpha and gamma subunits.

When to Used Etizola Powder?

Benzodiazapines are reported to only bind to receptors that contain gamma 2 and alpha 1/2/3/5 subunits. Alpha-1-containing receptors mediate the sedative effects of Etizolam Powder whereas alpha-2 and alpha-3 subunit-containing receptors mediate the anxiolytic effect.

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Etizolam Powder shows high potency and affinity towards GABA-A receptor with alpha 1 beta 2 gamma 2S subunit combination ¹. By binding to the regulatory site of the receptor, etizolam potentiates GABA transmission by facilitating the opening of GABA-induced chloride channels.

How to treat Etilaam Powder overdose?

Etizolam is a specific antagonist at PAFR. It inhibits PAF-induced platelet aggregation by inhibiting PAF binding to the receptors located on the surface of platelets with an IC50 of 22nM ⁵.

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