JWH-018 (also called AM-678 and 1-Pentyl-3-(1-naphthoyl)indole) is orally active when dissolved in a lipid, which can increase the duration significantly. It is a full agonist synthetic cannabinoid first synthesized by organic chemist John W. Huffman. Like other cannabinoids, JWH-018 is commonly smoked or vaporized to achieve a quick onset of effects and rapid offset.
